DP Biology · HL / SL · D - Continuity and Change

D2.1 Cell and nuclear division

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  1. Question 1

    A researcher counts cells in a section of human skin tissue under a microscope. Of the 250 cells observed, 200 are in interphase and 50 are in various stages of mitosis. What is the mitotic index of this tissue sample?
    No clue? Show me the answer
    Correct answerCorrect!Incorrect
    A0.20

    Step-by-step walkthrough

    Choose a solution method

    Method #1Approach 1

    Step 1: Identify the formula

    The mitotic index is calculated as: Mitotic Index=Total number of cellsNumber of cells in mitosis​

    Step 2: Extract the values

    The number of cells in mitosis = 50. The total number of cells = 250.

    Step 3: Calculate

    Mitotic Index=25050​=0.20

    Step 4: State the answer

    The mitotic index is 0.20, meaning 20% of cells are actively dividing.

    Method #2Approach 2

    Step 1: Identify what is being asked

    We need to find the mitotic index using cells in mitosis divided by total cells: 25050​.

    Step 2: Eliminate 0.80

    0.80 would result from 250200​, which is the fraction of cells in interphase, not mitosis. This is the wrong numerator.

    Step 3: Eliminate 0.25

    0.25 would result from 20050​ — dividing by the number of interphase cells rather than the total. This is an incorrect denominator.

    Step 4: Eliminate 4.00

    4.00 would result from 50200​, which inverts the correct ratio and uses the wrong values. A mitotic index greater than 1 is impossible.

    Step 5: Select the correct answer

    0.20 is correct: 25050​=0.20, representing 20% of cells in active division.

  2. Question 2

    A student observes a cell under a microscope and notes the following: the nuclear envelope is absent, chromosomes are clearly visible and thickening, and a spindle is beginning to assemble. Which phase of mitosis is this cell in?
    No clue? Show me the answer
    Correct answerCorrect!Incorrect
    BProphase

    Step-by-step walkthrough

    Choose a solution method

    Method #1Approach 1

    Step 1: List the observable features

    The cell shows: (1) nuclear envelope absent, (2) chromosomes condensing and becoming visible, (3) spindle beginning to form.

    Step 2: Match features to a phase

    Prophase is defined by chromosome condensation (chromatin → visible chromosomes), breakdown of the nuclear envelope, and assembly of the mitotic spindle.

    Step 3: Confirm the identification

    All three features match prophase perfectly. The chromosomes are still thickening (not yet maximally condensed for metaphase), and the spindle is only beginning to form, consistent with early-to-mid prophase.

    Step 4: State the answer

    The cell is in Prophase.

    Method #2Approach 2

    Step 1: Identify what is being asked

    We need to identify the mitotic phase from three key observations: no nuclear envelope, condensing chromosomes, and a forming spindle.

    Step 2: Eliminate Metaphase

    In Metaphase, chromosomes are fully condensed and aligned at the metaphase plate, and the spindle is complete — not 'beginning to assemble.' This does not match.

    Step 3: Eliminate Telophase

    In Telophase, the nuclear envelope is reforming (not absent) and chromosomes are decondensing. Both features are the opposite of what is described.

    Step 4: Eliminate Anaphase

    In Anaphase, sister chromatids are being pulled to opposite poles — they would appear as two separating groups. No chromosome movement is described here.

    Step 5: Select the correct answer

    Prophase matches all observations: nuclear envelope breakdown, chromosome condensation, and spindle assembly beginning.

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